Meaning

noun an extreme state of adversity; the lowest point of anything

noun the point below the observer that is directly opposite the zenith on the imaginary sphere against which celestial bodies appear to be projected

originUnknown. It has been suggested that it is from Arabic نَزِير (nazīr, “rare, trivial”), but if it is Arabic, perhaps more likely would be نَذِير (naḏīr, “auspicious, boding well (?)”). Represents the word 'rare' in Hebrew.

Etymology from Wiktionary, CC BY-SA 3.0