6 letters · 10 points in Scrabble
verb cause to go crazy; cause to lose one's mind
verb drive up the wall; go on someone's nerves
verb make mad
originReduced Anglicized form of Irish Ó Madadháin (“descendant of Madadhán”), a diminutive of madadh (“dog”).
Etymology from Wiktionary, CC BY-SA 3.0