Meaning

noun large shaggy-haired brown bison of North American plains

noun a city on Lake Erie in western New York (near Niagara Falls)

noun meat from an American bison

origin*(North America): Probably from buffalo (“American bison”) (Bison bison), since both cities are in regions that had wild herds at the time the names originated. Buffalo, New York was named after the Buffalo River, which an alternative etymology says is from French beau fleuve (“beautiful river”), but the more likely explanation is that it was named for the animal. *(South Africa): From buffalo…

Etymology from Wiktionary, CC BY-SA 3.0